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| Status |
Public on May 19, 2021 |
| Title |
Genomic modules and intramodular networks of susceptibility and resilience in multimodeled stress in male mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
It was our goal to discern the genomic signatures of the ventral hippocampus, in male mice after exposure to exogenous corticosterone, an animal model that induces a blunted response to stress. In addition to wildtype mice, we used mice heterozygous for the single nucleotide polymorphism of the gene encoding for brain-derived neurotrophic factor, BDNF Val66Met, a mouse model that shows susceptibility to stress.
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| Overall design |
Wild-type mice or BDNF Val66Met male mice were maintained on chronic oral corticosterone or vehicle for six weeks prior dissection of the ventral hippocampus and extraction of RNA for sequencing.
VV/WT = Wildtyple, VM/BDNF = Heterozygous BDNF Val66Met, VEH = vehicle, CORT = corticosterone
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| |
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| Contributor(s) |
Caradonna SG, Marrocco J, Einhorn NR |
| Citation(s) |
34848858 |
| |
| Submission date |
May 18, 2021 |
| Last update date |
Dec 13, 2021 |
| Contact name |
Jordan Marrocco |
| E-mail(s) |
jmarrocco@rockefeller.edu
|
| Phone |
2123278625
|
| Organization name |
The Rockefeller University
|
| Lab |
McEwen
|
| Street address |
1230 York Ave
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA730919 |
| SRA |
SRP320411 |
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