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| Status |
Public on May 19, 2021 |
| Title |
Identification of 5'isomiR in HCC patients. |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
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| Summary |
The microRNA (miRNA) processing is a critical step for production of mature miRNAs. Its dysregulation leads to the increase of miRNA isoforms with heterogenous 5’ ends (isomiRs), recognizing distinct target sites with a shifted seed sequence. Although some miRNA genes display productive expression of their 5’-isomiRs in cancers, how the production is controlled and how they impact on tumor progression are unexplored yet. In this study, we identified tumor-specific production of isomiRs and investigated biological function of isomiRs in liver cancer.
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| Overall design |
15 Normal liver (NL), 60 HCC (TG1=10, TG2=25, TG3=19, HPC=6) samples who underwent small RNA-Seq
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| Contributor(s) |
Yang HD, Eun J, Nam SW |
| Citation(s) |
35729324, 36599932 |
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| Submission date |
May 18, 2021 |
| Last update date |
Jun 01, 2023 |
| Contact name |
Hee Doo Hee Doo |
| E-mail(s) |
yhd9020@catholic.ac.kr
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| Organization name |
The Catholic Univ. of Korea
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| Street address |
Banpo-Dong Seocho-Gu
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| City |
Seoul |
| ZIP/Postal code |
06591 |
| Country |
South Korea |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (75)
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| Relations |
| BioProject |
PRJNA730731 |
| SRA |
SRP320296 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE174608_miRNA_expression_TPM.txt.gz |
85.2 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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