GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE174310 Query DataSets for GSE174310
Status Public on May 12, 2024
Title Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus
Organism Mycobacteroides abscessus ATCC 19977
Experiment type Expression profiling by high throughput sequencing
Summary Regulation of M. abscessus gene expression in WT or dosR mutant and treated with artemisinin
Overall design WT or DosR deletion mutant were cultured in 16 mL of Dubos browth +10% ADS and 0.05% Tween 80 starting at an OD of 0.05 in a T-25 flask (in horizontal position). The cultures were treated with 20 uM artemisinin or a DMSO control for 24 hours, RNA was extracted, llibraries generated, sequenced and differential gene expression analyzed.
Contributor(s) Belardinelli JM, Williams JT, Johnson BK, Abramovitch RB, Jackson M
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date May 12, 2021
Last update date May 12, 2024
Contact name Robert B. Abramovitch
Organization name Michigan State University
Department Microbiology and Molecular Genetics
Street address 567 Wilson Road
City East Lansing
State/province MI
ZIP/Postal code 48824
Country USA
Platforms (1)
GPL30122 Illumina HiSeq 2500 (Mycobacteroides abscessus ATCC 19977)
Samples (8)
GSM5291668 WT Rep 1, DMSO
GSM5291669 WT Rep 2, DMSO
GSM5291670 WT Rep 1, Artemisinin treated
BioProject PRJNA729413
SRA SRP319430

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE174310_WT_vs_WT_Artemisinin_GEO.xlsx 1.1 Mb (ftp)(http) XLSX
GSE174310_WT_vs_dosR_GEO.xlsx 1.0 Mb (ftp)(http) XLSX
GSE174310_dosR_vs_dosR_Artemisinin_GEO.xlsx 1.1 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap