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Series GSE173717 Query DataSets for GSE173717
Status Public on May 03, 2021
Title Six months of gender affirming hormone treatment modifies the methylome in the transgender population
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary The main objective was to carry out a prospective global CpG (cytosine-phosphate-guanine) methylation analysis before vs. after six months of gender affirming hormone treatment (GAHT), in a transgender population vs. a cisgender population.
 
Overall design A global CpG methylation analysis was performed on 16 transgender people before vs. after GAHT and compared to 16 cisgender people, using the Illumina© Infinium Human Methylation 850k BeadChip. Global methylation was analyzed with the Partek® Genomics® Suite program (false discovery rate correction FDR p < 0.05; fold change ≥ ±2) by a 3-way ANOVA test comparing populations by group, assigned sex at birth and GAHT. We added six contrast interactions: trans men (before vs. after), trans women (before vs. after), cis men vs. trans women (before and after), and cis women vs. trans men (before and after).
 
Contributor(s) Ramírez K, Fernández R, Collet S, Kiyar M, Delgado-Zayas E, Van Den Eynde T, Gómez-Gil E, T'Sjoen G, Guillamon A, Mueller SC, Pásaro E
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Submission date May 02, 2021
Last update date May 05, 2021
Contact name Rosa Fernandez
E-mail(s) rosa.fernandez@udc.es
Organization name University of A Coruña
Department Psychology
Lab Psychobiology
Street address Campus Elviña
City A Coruña
State/province None / N/A
ZIP/Postal code 15071
Country Spain
 
Platforms (1)
GPL23976 Illumina Infinium HumanMethylation850 BeadChip
Samples (48)
GSM5277297 blood_Cismen_pretreatment, rep1 [CM11]
GSM5277298 blood_Cismen_pretreatment, rep1 [CM17]
GSM5277299 blood_Cismen_pretreatment, rep1 [CM2]
Relations
BioProject PRJNA726827

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE173717_RAW.tar 681.2 Mb (http)(custom) TAR (of IDAT)
GSE173717_average_beta.txt.gz 144.4 Mb (ftp)(http) TXT
GSE173717_unmethylated_methylated_signal_intensities.txt.gz 244.5 Mb (ftp)(http) TXT
Processed data are available on Series record
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