|
| Status |
Public on May 01, 2021 |
| Title |
Transcriptomic analysis of Caenorhabditis elegans treated with mitochondrial Na+/Ca2+ exchanger inhibitor CGP37157 vs untreated control. |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We report that CGP37157 improved the evolution with age of the sarcomeric regular structure, delaying development of sarcopenia in C. elegans body wall muscle. Similarly, CGP37157 favoured the maintenance of a regular mitochondrial structure during aging. CGP37157 induced a four-fold increase in the expression of ncx-6, one of the C. elegans mitochondrial Na+/Ca2+ exchangers.
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| |
|
| Overall design |
Examination of 3 replicates of CGP37157 treated C.elegans and 3 replicates of control C.elegans.
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| |
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| Contributor(s) |
García-Casas P, Alvarez-Illera P, Gomez-Orte E, Cabello J, Fonteriz RI, Montero M, Alvarez J |
| Citation(s) |
34211399 |
| |
| Submission date |
Apr 30, 2021 |
| Last update date |
Jul 08, 2021 |
| Contact name |
Javier Alvarez |
| E-mail(s) |
jalvarez@ibgm.uva.es
|
| Phone |
+34 983184844
|
| Organization name |
IBGM, CSIC / Univerity of Valladolid
|
| Street address |
Calle Sanz y Forés, 3
|
| City |
Valladolid. |
| ZIP/Postal code |
47003 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL18730 |
Illumina HiSeq 1500 (Caenorhabditis elegans) |
|
| Samples (6)
|
| GSM5272994 |
WT C. elegans control rep.1 [Control_rep1_02_12] |
| GSM5272995 |
WT C. elegans control rep.2 [Control_rep2_04_12] |
| GSM5272996 |
WT C. elegans control rep.3 [Control_rep3_17_12] |
| GSM5272997 |
CGP37157 treated C.elegans rep1 [CGP_rep1_02_12] |
| GSM5272998 |
CGP37157 treated C.elegans rep2 [CGP_rep2_04_12] |
| GSM5272999 |
CGP37157 treated C.elegans rep3 [CGP_rep3_17_12] |
|
| Relations |
| BioProject |
PRJNA726525 |
| SRA |
SRP318012 |
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