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Series GSE173594 Query DataSets for GSE173594
Status Public on Nov 15, 2021
Title Ischemic heart disease selectively modifies the right atrial appendage transcriptome
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: This study aims to identify IHD-associated signature RNAs from the atrial myocardium and evaluate their ability to reflect disease severity or cardiac surgery outcomes.
Methods: We collected right atrial appendage (RAA) biopsies from 40 patients with invasive coronary angiography (ICA)-positive IHD undergoing coronary artery bypass surgery and from 8 patients ICA-negative for IHD (non-IHD) undergoing valvular surgery. Following RNA sequencing, RAA transcriptomes were analyzed against those 429 donors from the GTEx project without cardiac background.
Results: The IHD transcriptome was characterized using repressed RNA expressions in pathways for cell–cell contacts and mitochondrial dysfunction. Specifically, we identified the increased expressions of the CSRNP3, FUT10, SHD, NAV2-AS4, and hsa-mir-181 genes to correlate with the complexity of coronary artery obstructions or with a functional cardiac benefit from bypass surgery.
Conclusions: Our results provide an atrial myocardium–focused insight into IHD signature RNAs. The specific gene expression changes we characterized here pave the way for disease mechanism–based identification of biomarkers allowing for the early detection and treatment of IHD.
 
Overall design Atrial appendage mRNA profiles of invasive coronary angiography (ICA)-positive IHD undergoing coronary artery bypass surgery and ICA-negative for IHD (non-IHD) undergoing valvular surgery.
 
Contributor(s) Mulari S, Eskin A, Lampinen M, Nummi A, Nieminen T, Teittinen K, Ojala T, Kankainen M, Vento A, Laurikka J, Kupari M, Harjula A, Tuncbag N, Kankuri E
Citation(s) 34926599
Submission date Apr 29, 2021
Last update date Sep 09, 2024
Contact name Arda Eskin
E-mail(s) ardaeskin1@gmail.com
Organization name Middle East Technical University
Department Informatics Institute
Street address Universiteler Mah.
City Ankara
State/province Cankaya
ZIP/Postal code 06800
Country Turkey
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (46)
GSM5271522 (ICA)-positive IHD undergoing coronary artery bypass surgery, 01-03-15-RTL
GSM5271523 (ICA)-positive IHD undergoing coronary artery bypass surgery, 01-09-15-ES
GSM5271524 (ICA)-positive IHD undergoing coronary artery bypass surgery, 03-12-14-OL
Relations
BioProject PRJNA726237
SRA SRP317431

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE173594_GTExSamples_readme.txt 91 b (ftp)(http) TXT
GSE173594_Raw_gene_counts_matrix.txt.gz 2.9 Mb (ftp)(http) TXT
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Processed data are available on Series record
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