|
| Status |
Public on Jun 05, 2023 |
| Title |
ORC1 binds to cis-transcribed RNAs for efficient activation of human origins [ORC1_iCLIP] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
By investigating the RNA binding activity of human ORC1, we show that it interacts with RNAs transcribed at active origins, which is linked to ORC1 dynamic association to the chromatin and optimal origin firing in S phase.
|
| |
|
| Overall design |
ORC1 3XFlag iCLIP from nuclei of untreated HCT116 cells.
|
| |
|
| Contributor(s) |
Mas AM, Blázquez L, Ruiz de los Mozoa I, Huarte M |
| Citation missing |
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| |
| Submission date |
Apr 27, 2021 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Maite Huarte |
| E-mail(s) |
maitehuarte@unav.es
|
| Organization name |
CIMA
|
| Street address |
c/ Avd Pio XII, 55
|
| City |
Pamplona |
| State/province |
Navarra |
| ZIP/Postal code |
31008 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (9)
|
|
| This SubSeries is part of SuperSeries: |
| GSE173452 |
ORC1 binds to cis-transcribed RNAs for efficient activation of human origins |
|
| Relations |
| BioProject |
PRJNA725549 |
| SRA |
SRP316612 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173449_Flag_HCT116_NoTF_Up_Down_merge_grouped_cdna.bed.gz |
2.2 Mb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_NoTF_Up_Down_merge_grouped_cdna_norm.bigWig |
2.9 Mb |
(ftp)(http) |
BIGWIG |
| GSE173449_Flag_HCT116_NoTF_Up_Down_merge_grouped_cdna_peaks.bed.gz |
4.7 Kb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1-OE_HighRNase_Up_merge_grouped_cdna.bed.gz |
7.6 Mb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1-OE_HighRNase_Up_merge_grouped_cdna_norm.bigWig |
9.8 Mb |
(ftp)(http) |
BIGWIG |
| GSE173449_Flag_HCT116_ORC1-OE_HighRNase_Up_merge_grouped_cdna_peaks.bed.gz |
18.9 Kb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1_down_merge_grouped_cdna.bed.gz |
11.9 Mb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1_down_merge_grouped_cdna_norm.bigWig |
17.0 Mb |
(ftp)(http) |
BIGWIG |
| GSE173449_Flag_HCT116_ORC1_down_merge_grouped_cdna_peaks.bed.gz |
37.7 Kb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1_up_merge_grouped_cdna.bed.gz |
15.7 Mb |
(ftp)(http) |
BED |
| GSE173449_Flag_HCT116_ORC1_up_merge_grouped_cdna_norm.bigWig |
20.0 Mb |
(ftp)(http) |
BIGWIG |
| GSE173449_Flag_HCT116_ORC1_up_merge_grouped_cdna_peaks.bed.gz |
43.0 Kb |
(ftp)(http) |
BED |
| GSE173449_RAW.tar |
38.0 Mb |
(http)(custom) |
TAR (of BED) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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