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| Status |
Public on May 04, 2021 |
| Title |
Single cell RNA-sequencing reveals placenta cellular heterogeneity in adverse pregnancy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The placenta is a highly heterogeneous organ and is closely related to adverse pregnancy. The previous bulk sequencing of whole tissue could not show the characteristics of individual cells and the interactions between cells. Here, we select the placental tissues of the gestational diabetes group(GDM), preeclampsia group(PE), advanced age group(GL) and normal control group for single-cell sequencing in order to explain the mechanism of related diseases in more depth.nated spatial and temporal regulation of gene expression in the murine hindlimb determines the identity of mesenchymal progenitors and the development of diversity of musculoskeletal tissues they form. Hindlimb development has historically been studied with lineage tracing of individual genes selected a priori, or at the bulk tissue level, which does not allow for the determination of single cell transcriptional programs yielding mature cell types and tissues. To identify the cellular trajectories of lineage specification during limb bud development, we used single cell mRNA sequencing (scRNA-seq) to profile the developing murine hindlimb.
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| Overall design |
2 placenta samples from PE, GDM, the elderly group and the control group respectively.
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| Contributor(s) |
Yu B, Yang Y, Zhou W, Zhang B |
| Citation(s) |
34025588, 36111571 |
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| Submission date |
Apr 23, 2021 |
| Last update date |
Oct 31, 2022 |
| Contact name |
Yu Bin |
| E-mail(s) |
binyu@njmu.edu.cn
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| Organization name |
Changzhou Maternal And Child Health Care Hospital
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| Street address |
16 Dingxiang Road, Changzhou City, Jiangsu Province
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| City |
Changzhou |
| ZIP/Postal code |
213000 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA724666 |
| SRA |
SRP316035 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173193_RAW.tar |
480.0 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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