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| Status |
Public on Apr 20, 2023 |
| Title |
High-throughput lncRNA sequencing profile of ovarian granulosa cells in polycystic ovary syndrome |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Purpose:To examine different expression profiles of lncRNAs and mRNAs in ovarian granulosa cells (GCs) in PCOS patients and controls
Patients:6 GCs samples in each group were subjected to high-thoughput sequencing
Results:54,615 lncRNAs and 123,141 mRNAs were detected in this high-thoughput sequencing, and we identified 1049 differential expressed lncRNAs and 3246 mRNAs (fold-changeā§2, P-value<0.05). So far, we found 7 lncRNAs and 3mRNAs were validated consistent with sequence profile which were selected, randomly. There is still a large part that we have not verified yet.
Conclusion: Our study provides the detail analysis of GCs transcriptomes, generated by high-thoughput technology. This report also provides a framework for comparative investigations of PCOS. Our results revealed the expression of lncRNAs, mRNAs and part of circRNAs in PCOS, after more in-depth research in future, it can provide basic datas for studying the pathogenesis of PCOS.
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| Overall design |
The expression profile of mRNAs, lncRNAs in GCs of PCOS patients
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| Contributor(s) |
Shi Y, Zheng Y, Yang X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Apr 23, 2021 |
| Last update date |
Apr 20, 2023 |
| Contact name |
Yanjun Zheng |
| Organization name |
Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University
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| Street address |
Wenhua West Road
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| City |
Jinan |
| State/province |
Shandong Province |
| ZIP/Postal code |
250014 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA724012 |
| SRA |
SRP315997 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE173160_gene_count_matrix.txt.gz |
11.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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