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| Status |
Public on Apr 13, 2021 |
| Title |
Single Cell Dissection of Transcriptional Heterogeneity in HPV Positive and Negative Cervical Cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here we performed single-cell RNA sequencing of more than 30,000 of cells from HPV16+ and HPV- cervical cancer patients. We comprehensively revealed the heterogeneity of both the malignant cell populations and immune lineages in HPV+ and HPV- CC, as well as the cellular crosstalks with potential relevance to tumor progression. Moreover, our results demonstrated that distinct interaction patterns in HPV+ and HPV- groups could mediate similar functions or pathways, and we further constructed a three-cell interaction resource.
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| Overall design |
Four fresh samples were obtained from patients with cervical cancer who underwent concurrent chemoradiotherapy
>>> Submitter declares that the raw data have not been submitted due to patient privacy concerns. <<<
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| Contributor(s) |
Yang S, Zhang Y, Pang L, Xiao M, Quan F, Chen X, Liu Y, Cui Y, Du Y, Pang B, Xu J, Wang Y, Feng Y, Gu L, Zhang Y, Wang Z |
| Citation(s) |
38482016 |
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| Submission date |
Apr 12, 2021 |
| Last update date |
Mar 20, 2024 |
| Contact name |
Fei Quan |
| E-mail(s) |
quanfei1993@gmail.com
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| Organization name |
Harbin Medical University
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| Street address |
Baojian Road 157
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| City |
Harbin |
| ZIP/Postal code |
150086 |
| Country |
China |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA721342 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE171894_RAW.tar |
136.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Raw data not provided for this record |
| Processed data provided as supplementary file |
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