|
| Status |
Public on Dec 31, 2009 |
| Title |
Hepatic gene expression before and during interferon and ribavirin combination therapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Patients who cleared HCV viremia early during therapy tended to show favorable outcomes, whereas patients who needed a longer period to clear HCV had poorer outcomes. We explored the mechanisms of treatment resistance by comparing hepatic gene expression before and during treatment
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| Overall design |
We explored the mechanisms of treatment resistance by comparing hepatic gene expression before and during treatment. Liver biopsy was performed in 30 patients before and one week after starting combination therapy with IFN + Rib. Hepatocytes and liver-infiltrating lymphocytes (LILs) were obtained from 12 patients using laser capture micro dissection (LCM).
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| Contributor(s) |
Honda M, Nakamura M, Tateno M, Sakai A, Shimakami T, Shirasaki T, Yamashita T, Arai K, Yamashita T, Sakai Y, Kaneko S |
| Citation(s) |
20739080 |
| |
| Submission date |
Jul 18, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Masao Honda |
| E-mail(s) |
mhondag@gmail.com
|
| Phone |
0762652243
|
| Organization name |
Kanazawa University
|
| Department |
Gastroenterology
|
| Street address |
Takara-Machi 13-1
|
| City |
Kanazawa |
| ZIP/Postal code |
920-8641 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (108)
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| Relations |
| BioProject |
PRJNA119677 |
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