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| Status |
Public on Apr 10, 2021 |
| Title |
Fine-tuned repression of Drp1 driven mitochondrial fission primes a ‘stem/progenitor-like state’ to accelerate neoplastic transformation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Mitochondria based priming of a stem/progenitor-like state involves fine-tuned repression of the master regulator of mitochondrial fission, Drp1, and drives carcinogen induced transformation in a keratinocyte model
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| |
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| Overall design |
Comparison of scRNAseq data of parental HaCaT ketatinocyte line, their TCDD (1nM and 10nM) driven transformed counterparts, and after expression of control, weak and strong Drp1 shRNA.
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| |
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| Contributor(s) |
Spurlock B, Basu MK, Mitra K |
| Citation missing |
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| |
| Submission date |
Apr 09, 2021 |
| Last update date |
Apr 11, 2021 |
| Contact name |
Kasturi Mitra |
| E-mail(s) |
kasturi@uab.edu
|
| Organization name |
University of Alabama, Birmingham
|
| Department |
Genetics
|
| Street address |
University of Alabama, Birmingham
|
| City |
Birmingham |
| State/province |
Alabama |
| ZIP/Postal code |
35249 |
| Country |
USA |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA720889 |
| SRA |
SRP314202 |
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