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Series GSE171142 Query DataSets for GSE171142
Status Public on Jun 28, 2021
Title Characterizing the invasive tumor front of aggressive uterine adenocarcinoma and leiomyosarcoma
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. In this study we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression and methylation profiles of classified aggressive primary uterine adenocarcinomas and leiomyosarcomas.
 
Overall design Total genomic DNA from formalin-fixed paraffin-embedded (FFPE) tissue sections of microdissected invasive tumor front (ITF) of uterine adenocarcinomas (uADC) and leiomyosarcomas (uLMS) were processed on the Infinium MethylationEPIC array (850K). Samples that passed the quality controls (ADC=21, LMS=9) using GenomeStudio and BeadArray Controls Reporter (Illumina), were analyzed to asses their DNA methylation profile.
 
Contributor(s) Diaz-Lagares A, Lopez-Lopez R
Citation(s) 34150764, 36467415
Submission date Mar 30, 2021
Last update date Dec 16, 2022
Contact name Angel Diaz-Lagares
E-mail(s) angel.diaz.lagares@sergas.es
Phone 981955710
Organization name Health Research Institute of Santiago (IDIS)
Department ONCOMET
Lab Cancer Epigenomics. Epigenomics Unit
Street address C/ Choupana s/n
City Santiago de Compostela
State/province A Coruña
ZIP/Postal code 15706
Country Spain
 
Platforms (1)
GPL21145 Infinium MethylationEPIC
Samples (30)
GSM5219632 Invasive tumor front (ITF) of uterine adenocarcinoma 2
GSM5219633 Invasive tumor front (ITF) of uterine adenocarcinoma 6
GSM5219634 Invasive tumor front (ITF) of uterine adenocarcinoma 9
Relations
BioProject PRJNA718540

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE171142_RAW.tar 566.0 Mb (http)(custom) TAR (of IDAT)
GSE171142_signals.txt.gz 242.5 Mb (ftp)(http) TXT
Processed data included within Sample table
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