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| Status |
Public on May 27, 2021 |
| Title |
Whole blood transciptome analysis in severe Covid-19 patients and healthy donors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The identification of COVID-19 patients with high-risk of severe disease is a challenge in routine care. We performed blood RNA-seq gene expression analyses in severe hospitalized patients compared to healthy donors. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care.
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| Overall design |
Analysis of whole-blood gene expression profiles of 44 covid-19 patients and 10 Healthy donnors
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| Contributor(s) |
Lévy Y, Wiedemann A, Hejblum BP, Durand M, Lefebvre C, Surénaud M, Lacabaratz C, Perreau M, Foucat E, Déchenaud M, Tisserand P, Blengio F, Hivert B, Gauthier M, Cervantes-Gonzalez M, Bachelet D, Laouénan C, Bouadma L, Timsit J, Yazdanpanah Y, Pantaleo G, Hocini H, Thiébaut R |
| Citation(s) |
34127958 |
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| Submission date |
Mar 29, 2021 |
| Last update date |
Sep 06, 2021 |
| Contact name |
cecile lefebvre |
| E-mail(s) |
cecile.lefebvre@inserm.fr
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| Organization name |
INSERM U955_VRI
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| Street address |
51 Avenue du Marechal De Lattre de Tassigny
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| City |
Créteil |
| ZIP/Postal code |
94810 |
| Country |
France |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (54)
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| Relations |
| BioProject |
PRJNA718349 |
| SRA |
SRP312643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE171110_Data_RNAseq_norm_counts_geo.txt.gz |
8.1 Mb |
(ftp)(http) |
TXT |
| GSE171110_Data_RNAseq_raw_counts_geo.txt.gz |
4.4 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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