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| Status |
Public on Sep 02, 2021 |
| Title |
Gene expression profiling of CD45+CD11b+F4/80high macrophages and CD45+TCRbeta+CD8+ T cells in MC38 tumor of WT, muMt-/- or muMt-/- mice implanted with GABA pellet |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We characterized the tumor-infiltrating macrophages and CD8 T cells, and we found a pro-inflammatory signature of those cells in muMt-/- mice compared to those in WT mice. Furthermore, many target genes of inflammatory cytokines, such as the TNF target genes, highly expressed in muMt-/- mice, were downregulated by exogenous of GABA.
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| Overall design |
Examination one hundred of tumor-infiltrating macrophages and CD8 T cells freshly sorted from tumor of WT, muMt-/- or muMt-/- mice implanted with GABA pellet on day 7 after tumor inoculation
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| Contributor(s) |
Zhang B, Faragasan S, Hojo N, Shiroguchi K |
| Citation(s) |
34732892 |
| |
| Submission date |
Mar 24, 2021 |
| Last update date |
Nov 19, 2021 |
| Contact name |
Katsuyuki Shiroguchi |
| Organization name |
RIKEN
|
| Department |
Center for Biosystems Dynamics Research
|
| Lab |
Laboratory for Prediction of Cell Systems Dynamics
|
| Street address |
6-2-3 Furuedai
|
| City |
Suita |
| State/province |
Osaka |
| ZIP/Postal code |
565-0874 |
| Country |
Japan |
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| Platforms (1) |
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| Samples (36)
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| Relations |
| BioProject |
PRJNA716988 |
| SRA |
SRP311979 |
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