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| Status |
Public on Mar 25, 2021 |
| Title |
Molecular roadmap of the healthy stress response in the mouse hippocampus (single-nucleus) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. Here, we used a brief forced swim exposure to trigger a strong stress response in mice. Using multiomic profiling we characterize the stress-induced molecular events in the dorsal (dHC) and ventral (vHC) hippocampus over time, across molecular scales, and down to the level of cell types and single cells.
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| Overall design |
Here, we used a brief (6min) forced swim exposure and profiled the hippocampus using single-nucleus RNA-seq 45min after initiation of the experiment.
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| Contributor(s) |
von Ziegler LM, Germain P, Florio-Servou A, Waag R, Bohacek J, Gross F |
| Citation(s) |
35383160 |
| |
| Submission date |
Mar 24, 2021 |
| Last update date |
Apr 27, 2022 |
| Contact name |
Lukas Matthias von Ziegler |
| E-mail(s) |
lukasvonziegler@gmail.com
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| Organization name |
ETH Zürich
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| Department |
D-HESZ
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| Lab |
Molecular and Behavioral Neuroscience
|
| Street address |
Winterthurerstrasse 190
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| City |
Zürich |
| ZIP/Postal code |
8057 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA716952 |
| SRA |
SRP311944 |
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