NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE169148 Query DataSets for GSE169148
Status Public on Mar 30, 2022
Title Evaluation of tofacitinib in cutaneous sarcoidosis [Olink Explore 1536]
Organism Homo sapiens
Experiment type Other
Summary Sarcoidosis is a multisystem inflammatory disease and no molecularly targeted therapies exist. Here we evaluate the efficacy of tofacitinib (a JAK1/3 inhibitor) in an open-label trial of 10 patients with sarcoidosis and correlate clinical improvement with molecular parameters in blood and skin.
 
Overall design Blood samples were collected from participants at baseline and again after 6 months of therapy. Samples were compared to 11 healthy, roughly age matched controls. Blood was collected in EDTA-coated tubes and centrifuged; the buffy coat was removed and stored separately from the plasma, which was aliquoted and stored at -80ºC. Plasma was analyzed using the Olink Explore 1536 panel.
 
Contributor(s) Damsky W, Wang A, Young BD, Ayasun R, Ryu C, McGeary MK, Fazzone-Chettiar R, Pucar D, Gulati M, Miller EJ, Bosenberg M, Flavell RA, King B
Citation(s) 35668129
Submission date Mar 18, 2021
Last update date Jun 29, 2022
Contact name William Damsky
E-mail(s) william.damsky@yale.edu
Organization name Yale School of Medicine
Street address 333 Cedar St
City New Haven
State/province CT
ZIP/Postal code 06511
Country USA
 
Platforms (1)
GPL29882 Olink Human Proximity Extension Assay Explore 1536
Samples (31)
GSM5176932 Sarcoidosis patient 1 prior to treated with tofacitinib [Olink Explore 1536 panel]
GSM5176933 Sarcoidosis patient 1 after treated with tofacitinib for six months [Olink Explore 1536 panel]
GSM5176934 Sarcoidosis patient 2 prior to treated with tofacitinib [Olink Explore 1536 panel]
This SubSeries is part of SuperSeries:
GSE169149 Evaluation of tofacitinib in cutaneous sarcoidosis
Relations
BioProject PRJNA715584

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary data files not provided
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap