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Series GSE168172 Query DataSets for GSE168172
Status Public on Jan 17, 2022
Title RNA sequencing analysis of gene expression in the prefrontal cortex of mice treated with antidepressant drugs
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We performed high-throughput profiling of gene expression in mouse prefrontal cortex in response to antidepressant treatment. BALB/c mice were treated with sertraline, duloxetine, or water for three weeks. Then we performed forced swim test to check their antidepressant-like behavior. We divided these animals to responder and non-responder based on their behavior in the forced swim test. We then conducted the transcriptomics analysis and found specific and distinct genes in responder and non-responder mice. Our study provided deep insights into the understanding of the molecular mechanisms underlying the behavioral response to antidepressants.
Overall design BALB/c mice were treated with sertraline, duloxetine, or water for three weeks. Total 5 groups were set up: mice received water (E), sertraline for responder (F) and non-responder (G), duloxetine for responser (H) and non-responder (I). Three replicates were used for each group.
Web link
Contributor(s) Uchida S
Citation(s) 36712563
Submission date Mar 03, 2021
Last update date Mar 22, 2023
Contact name Shusaku Uchida
Organization name Kyoto University
Street address 53 Kawaharamachi, Sakyo-ku
City Kyoto
State/province Kyoto
ZIP/Postal code 606-8507
Country Japan
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (15)
GSM5133351 E1_rep1
GSM5133352 E1_rep2
GSM5133353 E1_rep3
BioProject PRJNA706392
SRA SRP309132

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE168172_RNA-Seq_Quantified.txt.gz 3.5 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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