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| Status |
Public on Jan 17, 2022 |
| Title |
RNA sequencing analysis of gene expression in the prefrontal cortex of mice treated with antidepressant drugs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We performed high-throughput profiling of gene expression in mouse prefrontal cortex in response to antidepressant treatment. BALB/c mice were treated with sertraline, duloxetine, or water for three weeks. Then we performed forced swim test to check their antidepressant-like behavior. We divided these animals to responder and non-responder based on their behavior in the forced swim test. We then conducted the transcriptomics analysis and found specific and distinct genes in responder and non-responder mice. Our study provided deep insights into the understanding of the molecular mechanisms underlying the behavioral response to antidepressants.
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| Overall design |
BALB/c mice were treated with sertraline, duloxetine, or water for three weeks. Total 5 groups were set up: mice received water (E), sertraline for responder (F) and non-responder (G), duloxetine for responser (H) and non-responder (I). Three replicates were used for each group.
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| Web link |
https://www.sciencedirect.com/science/article/pii/S2667174322000027?via%3Dihub
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| Contributor(s) |
Uchida S |
| Citation(s) |
36712563 |
| |
| Submission date |
Mar 03, 2021 |
| Last update date |
May 20, 2024 |
| Contact name |
Shusaku Uchida |
| E-mail(s) |
uchida.shusaku.3n@kyoto-u.ac.jp
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| Organization name |
Kyoto University
|
| Street address |
53 Kawaharamachi, Sakyo-ku
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| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
606-8507 |
| Country |
Japan |
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| Platforms (1) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA706392 |
| SRA |
SRP309132 |
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