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Series GSE167747 Query DataSets for GSE167747
Status Public on Dec 16, 2021
Title SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Single-cell RNA-seq of iPSC derived human kidney organoids. Single-nuclei RNA-seq data of COVID-19 patient autopsy kidney tissue. The current data was used to suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury as well as a pro-fibrotic environment which could explain acute kidney injury in COVID-19 patients and also long-term effects potentially leading to the development of chronic kidney disease.
Overall design CTR, iPSC kidney organoids; COVID, SARS-CoV-2 infected kidney organoids; COVID-19, SARS-CoV-2 infected kidney autopsy.

>>>Submitter states that raw data are not available due to patient privacy concerns<<<
Contributor(s) Jansen J, Reimer KC, Nagai JS, Schneider RK, Smeets B, Kramann R
Citation(s) 35032430
Submission date Feb 26, 2021
Last update date Mar 17, 2022
Contact name Ivan Gesteira Costa
Phone +49 241 80 89337
Organization name UKA RWTH Aachen
Department Joint Research Center for Computational Biomedicine
Lab Institute for Computational Genomics
Street address Pauwelsstr. 19
City Aachen
State/province Northrhine-Westphalia
ZIP/Postal code 52074
Country Germany
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM5112197 KR01
GSM5112198 KR02
GSM5112199 KR03
BioProject PRJNA705189

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE167747_RAW.tar 198.4 Mb (http)(custom) TAR (of MTX, TAR, TSV)
Raw data not provided for this record
Processed data provided as supplementary file

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