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| Status |
Public on Apr 01, 2021 |
| Title |
Cx3cl1 expression in the adipose tissue is downregulated during development of obesity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To assess changes in expression level of various chemokines and their receptors on diet-induced obesity, we analysed gene expression in adipose tissue of C56BL/6J mice fed a high-fat (HF) diet or normal chow diet for 8 weeks. HF diet-induced obese (DIO) mice showed adipose tissue inflammation and insulin resistance. Comprehensive gene expression analysis showed that MCP-1–CCR2 and CCL5–CCR5 signalling in epididymal white adipose tissue (eWAT) were enhanced during the development of obesity. Surprisingly, the gene expression of Cx3cl1 was decreased in the eWAT of DIO mice compared with lean mice. While Cx3cr1 expression showed no significant difference between DIO and lean mice. Decreased CX3CL1-CX3CR1 signalling in adipose tissue may also be involved in the development of obesity-induced adipose tissue inflammation and insulin resistance.
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| Overall design |
Eight-week old male C57BL/6J mice were fed for 8 weeks on a normal chow (CRF-1) or high-fat diet consisting of 60% fat.
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| Contributor(s) |
Nagashimada M, Kobori M |
| Citation(s) |
33765141 |
| |
| Submission date |
Feb 23, 2021 |
| Last update date |
Apr 04, 2021 |
| Contact name |
Mayumi Nagashimada |
| E-mail(s) |
nakanaga@staff.kanazawa-u.ac.jp
|
| Organization name |
Kanazawa University
|
| Street address |
5-11-80 Kodatsuno
|
| City |
Kanazawa |
| ZIP/Postal code |
920-0942 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA704269 |
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