|
| Status |
Public on Apr 10, 2022 |
| Title |
Rat model of breast cancer to dissect mechanisms of immune escape and immunotherapy sensitivity |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
NMU-induced sprague dawley rat model of breast cancer treated with immunotherapy to prevent tumor progression
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| |
|
| Overall design |
Bulk RNA-Seq: Gene expression of FACS sorted EpCAM+, SMA+ and double negative (DN) subpopulations from tumors from NMU-induced mammary tumors in rats that were treated with vehicle, anti-PD-L1 antibody, TGFBR1 inhibitor and combination treatment.
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| Contributor(s) |
Del Alcazar G, Rodrigo C, Anne T, Aleckovic M, Harper N, Xie S, Krop E, Lulseged B, Murphy K, Freeman G, Dillion D, Muthuswamy S, Kornelia P, Rojas E, Oliphant M |
| Citation(s) |
35446942 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R35 CA197623 |
Targeting intratumor heterogeneity in breast cancer |
DANA-FARBER CANCER INSTITUTE |
KORNELIA POLYAK |
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| |
| Submission date |
Feb 19, 2021 |
| Last update date |
Jul 11, 2022 |
| Contact name |
Kornelia Polyak |
| E-mail(s) |
kornelia_polyak@dfci.harvard.edu
|
| Phone |
617-632-2106
|
| Organization name |
Dana-Farber Cancer Institute
|
| Department |
Medical Oncology
|
| Lab |
Polyak
|
| Street address |
450 Brookline Ave
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
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| Samples (115)
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| Relations |
| BioProject |
PRJNA702999 |
| SRA |
SRP307126 |
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