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| Status |
Public on Jun 02, 2021 |
| Title |
Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-Inflammatory Signaling in Juvenile Offspring in Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To further detect possible developmental neurotoxic effects of nicotine in offspring and underlying mechanism, whole genome microarray analysis of the expression profile of hippocampus was performed on PND 20. Significant alterations in the expression of genes related to inflammatory, neurotransmitter and synapsis were observed in the hippocampus after maternal nicotine exposure, as compared to the vehicle control.
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| Overall design |
Hippocampal mRNA profiles of 20-day old offspring mice
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| |
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| Contributor(s) |
Zhou L, Tao X |
| Citation(s) |
34045967 |
| |
| Submission date |
Feb 07, 2021 |
| Last update date |
Jun 02, 2021 |
| Contact name |
Li Zhou |
| E-mail(s) |
zl9504@126.com
|
| Phone |
19856135604
|
| Organization name |
Anhui University of Science and Technology
|
| Department |
School of Medicine
|
| Street address |
168 Taifeng Road
|
| City |
Huainan |
| State/province |
AnHui |
| ZIP/Postal code |
232001 |
| Country |
Zimbabwe |
| |
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| Platforms (1) |
| GPL25015 |
Arraystar Mouse LncRNA microarray V3B (Agilent-055750 custom Probe Name version) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA700418 |
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