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| Status |
Public on Nov 09, 2022 |
| Title |
Type I interferon (IFN) response in USP18 knockout in THP-1 AML cells [ATAC-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Type I IFN induces IFN stimulated genes (ISGs) and exert varieties of immunomoduratory functions. However, it is not well characterized how ISGs are regulated by negative regulators of IFN signaling. Here, we analyzed the chromatin accessibility when combined with depletion of USP18, one of major negative regulators for IFN signaling.
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| Overall design |
ATAC-sequencing of control and USP18KO THP-1 cells with or without IFN treatment for 6 hours. For ATAC-sequencing, 2 biological replicates were prepared for each condition.
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| Contributor(s) |
Arimoto K, Troutman TD, Zhang D |
| Citation(s) |
36646704 |
| |
| Submission date |
Jan 25, 2021 |
| Last update date |
Feb 08, 2023 |
| Contact name |
Kei-ichiro Arimoto |
| E-mail(s) |
karimoto@health.ucsd.edu
|
| Organization name |
UCSD Moores Cancer Center
|
| Street address |
3855 Health Sciences Dr
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA694581 |
| SRA |
SRP303133 |
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