|
| Status |
Public on Jan 26, 2021 |
| Title |
Effect of Decitabine on SKM-1 and MDS-L Gene Expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to further study the mechanism of decitabine (DAC) on MDS cell lines, 1uM DAC was used to treat SKM-1 and MDS-L cell lines, and the molecular pathway changes regulated by DAC were explored. Genes whose expression changes more than 2.0 times after drug treatment are defined as regulated genes.
Taking the intersection change of the two cell lines, it was found that compared with the control, 541 genes were up-regulated in the intersection of gene changes treated with DAC, and 762 genes were down-regulated. Gene expression profile analysis shows that DAC can significantly affect various cell biological processes, including antiviral response, immune response, inflammatory response and cell apoptosis.
|
| |
|
| Overall design |
Decitabine-induced gene expression in SKM-1 and MDS-L cells was measured after 5 days exposure at dose of 1uM. The same number of cells were treated with DMSO as a control.
|
| |
|
| Contributor(s) |
Zhang Z, Xv F |
| Citation(s) |
33584800 |
| |
| Submission date |
Jan 13, 2021 |
| Last update date |
Feb 16, 2021 |
| Contact name |
Zheng Zhang |
| E-mail(s) |
davidandy33211@gmail.com
|
| Organization name |
Shanghai Jiao Tong University
|
| Street address |
YiShan Road 600
|
| City |
Shanghai |
| ZIP/Postal code |
200233 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA691877 |
Less...
More...