|Public on Feb 15, 2021
|Association of RERG Expression to Female Survival Advantage in Malignant Pleural Mesothelioma I
|Expression profiling by array
|Sex differences in incidence, prognosis, and treatment response have been described for many cancers. In malignant pleural mesothelioma (MPM), a lethal disease associated with asbestos exposure, men outnumber women 4 to 1, but women consistently live longer than men following surgery-based therapy. This study investigated whether tumor expression of genes associated with estrogen signaling could potentially explain observed survival differences. Two microarray datasets of MPM tumors were analyzed to discover estrogen-related genes associated with survival. A validation cohort of MPM tumors was selected to balance the numbers of men and women and control for competing prognostic influences. The RAS like estrogen regulated growth inhibitor (RERG) gene was identified as the most differentially-expressed estrogen-related gene in these tumors and predicted prognosis in discovery datasets. In the sex-matched validation cohort, low RERG expression was significantly associated with increased risk of death among women. No association between RERG expression and survival was found among men, and no relationship between estrogen receptor protein or gene expression and survival was found for either sex. Additional investigations are needed to elucidate the molecular mechanisms underlying this association and its sex specificity.
|This study investigated whether tumor expression of genes associated with estrogen signaling could potentially explain observed survival differences between men and women affected by malignant pleural mesothelioma.
|De Rienzo A, Coleman MH, Yeap BY, Severson DT, Wadowski B, Gustafson CE, Jensen RV, Chirieac LR, Richards WG, Bueno R
|Dec 22, 2020
|Last update date
|Aug 25, 2022
|Assunta De Rienzo
|Brigham and Women's Hospital
|75 Francis Street
|[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
|This SubSeries is part of SuperSeries:
|Association of RERG Expression to Female Survival Advantage in Malignant Pleural Mesothelioma