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Series GSE163488 Query DataSets for GSE163488
Status Public on Dec 19, 2020
Title Transgenic mice overexpressing the LH receptor in the female reproductive system spontaneously develop endometrial tumour masses
Organism Mus musculus
Experiment type Expression profiling by array
Summary We developed transgenic mice which overexpress the human LH-R transcript in the female reproductive tract, under the control of the oviduct-specific glycoprotein mouse promoter (mogp-1). The uteri of young TG mice showed signs of increased proliferation and trans-differentiation in the endometrial layer. A transcriptomic analysis,further confirmed by immunohistochemistry, showed that up regulated genes are mainly involved in cell cycle control, while down regulated genes are related to the immune system and the metabolism of xenobiotics. Aged TG females developed tumor masses resembling an EC:
Overall design Gene expression profiling of primary masses and uteri from TG LH-R overexpressing animals. It has been compared with that of uteri from WT animals.
Contributor(s) Lottini T, Iorio J, Carraresi L, Pillozzi S, Lastraioli E, Duranti C, Sala C, Armenio M, Noci I, Arcangeli A
Citation(s) 33893331
Submission date Dec 18, 2020
Last update date May 06, 2021
Contact name Annarosa Arcangeli
Organization name University of Firenze
Street address Viale Morgagni 50
City Firenze
State/province FI
ZIP/Postal code 50134
Country Italy
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (8)
GSM4979947 US45103023_252665519150_S02_GE1-v1_95_Feb07_1_3
GSM4979948 US45103023_252665519150_S02_GE1-v1_95_Feb07_1_4
GSM4979949 US45103023_252665519150_S02_GE1-v1_95_Feb07_1_1
BioProject PRJNA686376

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE163488_RAW.tar 71.1 Mb (http)(custom) TAR (of TXT)
GSE163488_Results.xlsx 10.7 Mb (ftp)(http) XLSX
Processed data are available on Series record

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