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| Status |
Public on Jan 07, 2021 |
| Title |
Expressions of MicroRNA in Mouse Kidney with Unilateral Ureteral Obstruction |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Renal fibrosis is the final common pathway for chronic kidney disease. However, the detailed mechanisms and therapeutic strategies for renal fibrosis have not been established. MicroRNAs (miRNAs) are small, non coding RNAs that regulate various pathological conditions and diseases. Previous studies reported that miRNAs play a pivotal role in renal fibrosis. However, the role of miRNAs in renal fibrosis has not been completely elucidated. Therefore, in this study, miRNAs on renal fibrosis was investigated in a renal fibrosis mouse model generated by unilateral ureteral obstruction. MiRNA microarray analysis revealed 109 miRNAs that were upregulated more than 2 fold and 113 miRNAs that were downregulated less than 0.5 fold in the kidney of UUO mice compared with control mice.
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| Overall design |
Kidney tissue obtained 7 days after unilateral ureteral obstruction surgery or sham surgery was used for microarray analyses (n = 4, each group ).
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| Contributor(s) |
Kaneko S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 07, 2020 |
| Last update date |
Jan 08, 2021 |
| Contact name |
Shohei Kaneko |
| E-mail(s) |
d1909@jichi.ac.jp
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| Phone |
0486472111
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| Organization name |
Saitama Medical Center, Jichi Medical University
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| Street address |
1-847 Amanuma-cho, Omiya-ku
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| City |
Saitama |
| State/province |
Saitama |
| ZIP/Postal code |
330-8503 |
| Country |
Japan |
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| Platforms (1) |
| GPL21265 |
Agilent-070155 Mouse miRNA Microarray (miRBase Release 21.0, miRNA ID version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA683028 |
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