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| Status |
Public on Apr 26, 2021 |
| Title |
Single cell transcriptional zonation of human psoriasis whole skin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To explore the cellullar and molecular alteration of human psoriasis, we collected full-thickness skin from the lesion region of 3 patients and the similar region of 3 healthy donors, and submit for single cell RNA sequencing (scRNAseq) with 10x genomics (V3.1). The transcriptional landscape of human psoriasis whole skin provide a unique view of immuno-regulation among skin cell types.
1. "Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis",<Cell Death Dis.>, 2021 May 6;12(5):450.
https://yz-studio.shinyapps.io/shinyapph5ad/
2. "Integrative single-cell transcriptomic investigation unveils long non-coding RNAs associated with localized cellular inflammation in psoriasis" <Front Immunol>2023 Sep 26:14:1265517.
Integrated dataset: 106,675 cells from 11 healthy human skin and 79,887 cells from 9 psoriatic human skin
https://yz-studio.shinyapps.io/psoriaticskincellatlas2/
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| Overall design |
Single cell RNA-seq study of human psoriasis skin
*** Revision: The raw data has been uploaded to the Genome Sequence Archive (GSA) for human data, and the GSA ID is HRA004936, link: https://ngdc.cncb.ac.cn/gsa-human/browse/HRA004936 ***
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| Web link |
https://yz-studio.shinyapps.io/psoriaticskincellatlas2/
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| Contributor(s) |
Hu Y, Gao Y, Li Y |
| Citation(s) |
33958582 |
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| Submission date |
Nov 25, 2020 |
| Last update date |
Feb 24, 2024 |
| Contact name |
Yizhou Hu |
| E-mail(s) |
yizhou.hu@ki.se
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| Organization name |
Karolinska Institute
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| Street address |
C6 , Biomedicum Karolinska, Solnavägen 9,
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| City |
Solna |
| State/province |
Stockholm |
| ZIP/Postal code |
17165 |
| Country |
Sweden |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA680805 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE162183_Raw_gene_counts_matrix.tab.gz |
76.7 Mb |
(ftp)(http) |
TAB |
| GSE162183_Raw_gene_counts_matrix_LoomFile.loom.gz |
143.6 Mb |
(ftp)(http) |
LOOM |
| Raw data not provided for this record |
| Processed data are available on Series record |
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