|
| Status |
Public on Nov 29, 2020 |
| Title |
Expression profiling with RNA-seq between mouse AML cells with or without chemotherapy |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reported the expression profiling between mouse AML cells with or without chemotherapy. For this purpose, mouse AML cells were harvested from mice treated with or without chemotherapy drugs on day 7. Gene expression analysis of AML cells with or without chemotherapy identified clearly distinguishable transcriptomic profiles. GO analysis revealed that gene alterations after chemotherapy were related to immune response, RNA biology and several metabolomic processes. mTORC1 signal-related GSEA signatures were also enriched in AML cells after chemotherapy including those of stemness and impaired differentiation.
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| |
|
| Overall design |
Examining expression profilng bwtween the AML cells with or without chemothrapy
|
| |
|
| Contributor(s) |
Oki T, Kato H, Mercier F, Scadden D |
| Citation(s) |
33431855 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 CA194596 |
(PQC2) Localization as a determinant of cancer dormancy |
MASSACHUSETTS GENERAL HOSPITAL |
David T Scadden |
| U54 CA193461 |
Evolution and Treatment Response of Brain, Breast, and Hematologic Malignancies |
DANA-FARBER CANCER INSTITUTE |
Franziska Michor |
| R01 CA194596 |
(PQC2) Localization as a determinant of cancer dormancy |
MASSACHUSETTS GENERAL HOSPITAL |
Charles P. Lin |
|
| |
| Submission date |
Nov 14, 2020 |
| Last update date |
Jan 19, 2021 |
| Contact name |
Toshihiko Oki |
| Organization name |
Massachusetts General Hospital
|
| Department |
Center for Regenerative Medicine
|
| Street address |
185 Cambridge Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
| GSM4908653 |
mouse AML cells without chemotherapy mouse 1 |
| GSM4908654 |
mouse AML cells without chemotherapy mouse 2 |
| GSM4908655 |
mouse AML cells without chemotherapy mouse 3 |
| GSM4908656 |
mouse AML cells without chemotherapy mouse 4 |
| GSM4908657 |
mouse AML cells without chemotherapy mouse 5 |
| GSM4908658 |
mouse AML cells without chemotherapy mouse 6 |
| GSM4908659 |
mouse AML cells without chemotherapy mouse 7 |
| GSM4908660 |
mouse AML cells with chemotherapy mouse 1 |
| GSM4908661 |
mouse AML cells with chemotherapy mouse 2 |
| GSM4908662 |
mouse AML cells with chemotherapy mouse 3 |
| GSM4908663 |
mouse AML cells with chemotherapy mouse 4 |
| GSM4908664 |
mouse AML cells with chemotherapy mouse 5 |
|
| Relations |
| BioProject |
PRJNA678444 |
| SRA |
SRP292580 |
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