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| Status |
Public on Oct 14, 2009 |
| Title |
Effect of heteronemin on gene expression profiles in chronic myelogenous K562 leukemia cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Heteronemin is a sesterterpene first isolated from Hyrtios Erecta in 1976. In this study we decided to investigate the anti-cancer and anti-inflammatory potential of this marine natural compound at the transcriptomic level in chronic myelogenous K562 leukemia cells. Our results suggest that this sesterterpene has an impact on cell cycle, apoptosis, the MAP kinase signalling pathway and the NF-kappaB transcription factor.
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| Overall design |
We used four experimental conditions : untreated cells, cells treated with heteronemin, cells treated with TNFalpha and cells co-treated with TNFalpha and heteronemin. Experiments were performed in three biological replicates including two technical replicates. Technical replicates were hybridized as dye-swaps. Dye-swap between replicates 1 and 2, 3 and 4, 5 and 6, respectively.
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| Contributor(s) |
Cerella C, Eifes S, Schumacher M, Chateauvieux S, Dicato M, Diederich M |
| Citation(s) |
19814997 |
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| Submission date |
May 08, 2009 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Marc Diederich |
| E-mail(s) |
marcdiederich@snu.ac.kr
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| Organization name |
Seoul National University
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| Department |
College of Pharmacy
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| Lab |
Molecular Oncology
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| Street address |
Gwanak-ro, Gwanak-gu, 1
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| City |
Seoul |
| ZIP/Postal code |
08826 |
| Country |
South Korea |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (18)
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| GSM401041 |
TNFalpha-treated cells vs. untreated control cells, replicate 1 |
| GSM401042 |
TNFalpha-treated cells vs. untreated control cells, replicate 2 |
| GSM401043 |
TNFalpha-treated cells vs. untreated control cells, replicate 3 |
| GSM401044 |
TNFalpha-treated cells vs. untreated control cells, replicate 4 |
| GSM401045 |
TNFalpha-treated cells vs. untreated control cells, replicate 5 |
| GSM401046 |
TNFalpha-treated cells vs. untreated control cells, replicate 6 |
| GSM401047 |
Heteronemin-treated cells vs. untreated control cells, replicate 1 |
| GSM401048 |
Heteronemin-treated cells vs. untreated control cells, replicate 2 |
| GSM401049 |
Heteronemin-treated cells vs. untreated control cells, replicate 3 |
| GSM401050 |
Heteronemin-treated cells vs. untreated control cells, replicate 4 |
| GSM401051 |
Heteronemin-treated cells vs. untreated control cells, replicate 5 |
| GSM401052 |
Heteronemin-treated cells vs. untreated control cells, replicate 6 |
| GSM401053 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 1 |
| GSM401054 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 2 |
| GSM401055 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 3 |
| GSM401056 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 4 |
| GSM401057 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 5 |
| GSM401058 |
Heteronemin & TNFalpha co-treated cells vs.TNFalpha-treated cells, replicate 6 |
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| Relations |
| BioProject |
PRJNA115379 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE16026_RAW.tar |
126.4 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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