|
| Status |
Public on Oct 23, 2020 |
| Title |
Differential gene expression profiles by septin 2 suppression and TNF-a treatment in human microvascular endothelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Arrangements of juntional proteins of endothelial monolayers were altered by both septin 2 KD and TNF-a treatment. Therefore, differential gene expression profiles by septin 2 KD comapred to control and TNF-a treatment compared to untreat were analyzed using RNA-seq.
|
| |
|
| Overall design |
HDMVECs were suppressed with septin 2 and RNA-seq was performed. HDMVECs were treated with TNF-a overnight and RNA-seq was perfomed.
|
| |
|
| Contributor(s) |
Kim J, Cooper J |
| Citation(s) |
33147991 |
| |
| Submission date |
Oct 22, 2020 |
| Last update date |
Jan 22, 2021 |
| Contact name |
Joanna Kim |
| E-mail(s) |
joanna.kim@wustl.edu
|
| Phone |
3143624606
|
| Organization name |
Washington University
|
| Street address |
660 S Euclid Ave
|
| City |
St. Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (8)
|
| GSM4849557 |
human microvascular endothelial cells-Control 1 |
| GSM4849558 |
human microvascular endothelial cells-Control 2 |
| GSM4849559 |
human microvascular endothelial cells-Septin 2 suppression 1 |
| GSM4849560 |
human microvascular endothelial cells-Septin 2 suppression 2 |
| GSM4849561 |
human microvascular endothelial cells-Untreated 1 |
| GSM4849562 |
human microvascular endothelial cells-Untreated 2 |
| GSM4849563 |
human microvascular endothelial cells-TNF-a treatment 1 |
| GSM4849564 |
human microvascular endothelial cells-TNF-a treatment 2 |
|
| Relations |
| BioProject |
PRJNA670735 |
| SRA |
SRP288211 |
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