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Series GSE15824 Query DataSets for GSE15824
Status Public on Mar 18, 2011
Title Gene expression profiling of human gliomas and human glioblastoma cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149) was performed. Normal brain tissue (NB) and normal human astrocytes (NHA) were used as a control. Kinase expression in each tumor was compared to expression in normal brain and expression values from normal human astrocytes were used as an additional control.

Keywords: Kinase expression in each tumor was compared to expression in normal brain and expression values from normal human astrocytes were used as an additional control.
 
Overall design Frozen tissue samples of human gliomas and normal brain obtained from the operating room were processed according to the guidelines of the Ethical Committee of the University Hospitals of Basel. Human brain tumor cell lines were derived from human patients. The BS149 cell line was generated at the University of Basel, Switzerland while the “LN” series were a kind gift of Erwin van Meir in Lausanne, Switzerland. Normal human astrocytes (NHAs) were purchased by Cambrex (Walkersville, MD) and cultured according to manufacturer’s recommendations.
 
Contributor(s) Morin PJ, Grzmil M, Oakeley EJ, Hemmings BA, Merlo A, Lino MM
Citation(s) 21406405
Submission date Apr 24, 2009
Last update date Mar 25, 2019
Contact name Michal Grzmil
E-mail(s) michal.grzmil@fmi.ch
Phone +41 61-6978565
Fax +41-61-6973976
Organization name Friedrich Miescher Institute for Biomedical Research
Department Growth control
Lab 3.46
Street address Maulbeerstrasse 66
City Basel
ZIP/Postal code 4058
Country Switzerland
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (45)
GSM397626 Glioblastoma_1
GSM397627 Glioblastoma_2
GSM397628 Glioblastoma_3
Relations
BioProject PRJNA116745

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15824_RAW.tar 195.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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