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| Status |
Public on Feb 09, 2021 |
| Title |
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls
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| |
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| Overall design |
Sequencing of RNA and BCR was performed from FACS-sorted activated B cells (CD38high CD27high) from the peripheral blood of 9 COVID-19 ICU patients (one at 2 different time points) and 3 healthy controls, using the 10X Genomics platform with the Single Cell 5’ Library & Gel Bead Kit
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| |
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| Contributor(s) |
Tizian C, Ferreira-Gomes M, Heinz GA, Lehmann K, Guerra G, Heinrich F, Durek P, Mashreghi M |
| Citation(s) |
33785765 |
| |
| Submission date |
Sep 16, 2020 |
| Last update date |
Apr 20, 2021 |
| Contact name |
Pawel Durek |
| E-mail(s) |
pawel.durek@drfz.de
|
| Organization name |
Deutsches Rheuma-Forschungszentrum
|
| Street address |
Charitéplatz 1
|
| City |
Berlin |
| ZIP/Postal code |
10117 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (13)
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| This SubSeries is part of SuperSeries: |
| GSE158038 |
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response |
|
| Relations |
| BioProject |
PRJNA663837 |
| SRA |
SRP282580 |
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