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Status |
Public on Feb 09, 2021 |
Title |
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response (Activated B cells, set 1) |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Single cell transcriptome and BCR sequencing of FACS-sorted activated B cells of the peripheral blood of COVID-19 ICU patients and healthy controls
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Overall design |
Sequencing of RNA and BCR was performed from FACS-sorted activated B cells (CD38high CD27high) from the peripheral blood of 9 COVID-19 ICU patients (one at 2 different time points) and 3 healthy controls, using the 10X Genomics platform with the Single Cell 5’ Library & Gel Bead Kit
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Contributor(s) |
Tizian C, Ferreira-Gomes M, Heinz GA, Lehmann K, Guerra G, Heinrich F, Durek P, Mashreghi M |
Citation(s) |
33785765 |
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Submission date |
Sep 16, 2020 |
Last update date |
Apr 20, 2021 |
Contact name |
Pawel Durek |
E-mail(s) |
pawel.durek@drfz.de
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Organization name |
Deutsches Rheuma-Forschungszentrum
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Street address |
Charitéplatz 1
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City |
Berlin |
ZIP/Postal code |
10117 |
Country |
Germany |
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Platforms (1) |
GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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Samples (13)
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This SubSeries is part of SuperSeries: |
GSE158038 |
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response |
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Relations |
BioProject |
PRJNA663837 |
SRA |
SRP282580 |