|
| Status |
Public on Jul 15, 2005 |
| Title |
Conditional activation of B-catenin in adult mouse epidermis for 0, 1, or 7 days |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Expression of deltaNB-cateninER allows the time and duration of B-catenin activation to be controlled precisely through the application of 4OHT. We have shown that B-catenin activation in adult mouse epidermis stimulates de novo hair follicles and the formation of a new bulge and melanocyte niche. We utilize Affymetrix Mouse Genome 430A 2.0 oligonucleotide arrays to investigate the differential regulation of RNA in skin from 7 week old female deltaNB-cateninER transgenic mice following 0, 1, or 7 days B-catenin activation in the epidermis. RNA from age and sex matched wild-type littermates was used as a control.
Keywords = Mouse
Keywords = Affymetrix
Keywords = Skin
Keywords = Hair
Keywords = Epidermis
Keywords = Keratinocyte
Keywords = B-catenin
Keywords = Stem Cell
Keywords: time-course
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| Contributor(s) |
Silva-Vargas V, Lo Celso C, Ofstad TA, Watt FM |
| Citation(s) |
15992546 |
| |
| Submission date |
Jul 21, 2004 |
| Last update date |
Jan 08, 2019 |
| Contact name |
Fiona M Watt |
| E-mail(s) |
fiona.watt@cancer.org.uk
|
| Phone |
020 7242 0200 3527
|
| Organization name |
Cancer Research UK
|
| Department |
Keratinocyte
|
| Lab |
Fiona Watt Lab
|
| Street address |
44 Lincolns Inn Fields
|
| City |
London |
| ZIP/Postal code |
E3 5NZ |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL339 |
[MOE430A] Affymetrix Mouse Expression 430A Array |
|
| Samples (16)
|
| GSM26935 |
K14deltaNB-cateninER Time 0 replicate 1 |
| GSM26938 |
K14deltaNB-cateninER Time 0 replicate 2 |
| GSM26939 |
K14deltaNB-cateninER Time 1 replicate 1 |
| GSM26940 |
K14deltaNB-cateninER Time 1 replicate 2 |
| GSM26941 |
K14deltaNB-cateninER Time 1 replicate 3 |
| GSM26942 |
K14deltaNB-cateninER Time 7 replicate 1 |
| GSM26943 |
K14deltaNB-cateninER Time 7 replicate 2 |
| GSM26944 |
K14deltaNB-cateninER Time 7 replicate 3 |
| GSM26945 |
Wild Type Time 0 replicate 1 |
| GSM26946 |
Wild Type Time 0 replicate 2 |
| GSM26947 |
Wild Type Time 0 replicate 3 |
| GSM26948 |
Wild Type Time 1 replicate 1 |
| GSM26949 |
Wild Type Time 1 replicate 2 |
| GSM26950 |
Wild Type Time 1 replicate 3 |
| GSM26951 |
Wild Type Time 7 replicate 1 |
| GSM26952 |
Wild Type Time 7 replicate 2 |
|
| Relations |
| BioProject |
PRJNA90723 |
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