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| Status |
Public on Sep 11, 2020 |
| Title |
circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here, we have mapped high-confidence circRNA inventories of mouse embryonic stem cells, neuronal progenitor cells and in differentiated glutamatergic neurons and identify hundreds of differentially expressed circRNAs. By screening a panel of candidate circRNAs for a potential function in neuronal differentiation, we found that knockdown of circZNF827 significantly induces expression of key neuronal markers while slowing cell proliferation, suggesting that this molecule normally negatively regulates neuronal differentiation.
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| Overall design |
RNAseq of total and RNAseR treated RNA from neuronal differentiation of mESCs
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| |
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| Contributor(s) |
Damgaard CK, Hollesen A, Hansen TB |
| Citation(s) |
33174841 |
| |
| Submission date |
Sep 10, 2020 |
| Last update date |
Dec 11, 2020 |
| Contact name |
Thomas B Hansen |
| E-mail(s) |
tbh@mbg.au.dk
|
| Phone |
20733619
|
| Organization name |
MBG, Aarhus University
|
| Street address |
C.F. Moellers Alle 3, build 1130
|
| City |
Aarhus C |
| State/province |
State... |
| ZIP/Postal code |
8000 |
| Country |
Denmark |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA662781 |
| SRA |
SRP281978 |
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