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Status |
Public on Sep 10, 2020 |
Title |
Cranial manipulation modulates cholinergic pathway gene expression in an animal model of age-related cognitive decline |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
In this study, we examine the effect of cranial osteopathic manipulation (COM) on gene expression, in an animal model for age-related cognitive decline (aged rats). We found that COM significantly affected the expression of 36 genes in the neuronal pathway (False Discovery Rate (FDR) < 0.004). The top five neuronal genes with the largest fold-change (Slc5a7, Chat, Slc18a3, Adcy5 and Cacna2d2, >2-fold change, FDR<0.004) are part of the cholinergic neurotransmission mechanism, which is known to affect cognitive function.
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Overall design |
Compare gene expression from RNA sequencing of tissue samples from prefrontal cortex of aged rats that have undergone cranial osteopathic manipulation to aged rats that did not receive the treatment
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Contributor(s) |
Anandakrishnan R, Tobey H, Klein BG, Costa BM |
Citation(s) |
34995434 |
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Submission date |
Sep 09, 2020 |
Last update date |
Jan 29, 2022 |
Contact name |
Ramu Anandakrishnan |
E-mail(s) |
ramu@vt.edu
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Phone |
703-403-0234
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Organization name |
Edward Via College of Osteopathic Medici
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Department |
Biomedical Sciences
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Lab |
Molecular Mechanism of Disease
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Street address |
2265 Kraft Dr
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City |
Blacksburg |
State/province |
VA |
ZIP/Postal code |
24060 |
Country |
USA |
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Platforms (1) |
GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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Samples (6)
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Relations |
BioProject |
PRJNA662592 |
SRA |
SRP281885 |