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| Status |
Public on Jan 10, 2022 |
| Title |
Comparison of RNA sequencing profiles in domed and flat colonies of ocular surface epithelial stem cells induced from human pluripotent stem cell |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RNA-seq analysis revealed that genes associated with lacrimal gland development, such as BARX2, SIX1, SIX2, SOX9, and KRT15, were upregulated in domed colonies compared to flat colonies. In flat colonies, mucosal epithelial keratin, KRT13 and the corneal epithelial progenitor cell markers, CDH2 and NGFR were up-regulated, along with YAP1 and its downstream genes, CTGF and CYR61, which are involved in epithelial development.
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| Overall design |
RNA sequencing profiles of domed and flat colonies of ocular surface epithelial stem cells
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| Contributor(s) |
Okubo T, Hayashi R |
| Citation(s) |
35444274 |
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| Submission date |
Sep 08, 2020 |
| Last update date |
Apr 24, 2022 |
| Contact name |
Toru Okubo |
| E-mail(s) |
tookubo@rohto.co.jp
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| Organization name |
Rohto Pharmaceutical
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| Department |
Basic Research Development Division
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| Lab |
Cell Technology Group
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| Street address |
6-5-4 Kunimidai
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| City |
Kizugawa |
| State/province |
Kyoto |
| ZIP/Postal code |
619-0216 |
| Country |
Japan |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA662372 |
| SRA |
SRP281604 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE157678_raw_counts.txt.gz |
242.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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