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Series GSE157628 Query DataSets for GSE157628
Status Public on Oct 02, 2020
Title Transcriptome-wide Analysis of Intracranial Artery in Patients with Moyamoya Disease Showing Up-regulation of Immune Response, and Down-regulation of Oxidative Phosphorylation and DNA Repair
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Micro-samples of the middle cerebral artery (MCA) were collected from patients with MMD (n=11) and those with control (n=9). Using microarray techniques, transcriptome-wide analysis was performed. Comparison of the MCA gene expression between patients with MMD and control detected 62 and 26 genes whose expression was significantly (P<0.001, fold change>2) up- or down-regulated in the MCA of MMD. Gene set enrichment analysis of genes expressed in the MCA of MMD revealed positive correlations with genes involved in antigen processing and presentation, dendric cells pathway, cytokine pathway, and interleukin 12 pathway, whereas negative correlations with genes involved in oxidative phosphorylation and DNA repair. In addition, quantitative polymerase chain reaction analysis confirmed decreased gene expressions of tetraspanin 2 and ras homolog family member Q in MCA of MMD (P<0.05).
 
Overall design Micro-samples of the middle cerebral artery (MCA) were collected from patients with MMD (n=11) and those with control (n=9).
 
Contributor(s) Yokoyama K, Kanamori F
Citation(s) 34469870
Submission date Sep 08, 2020
Last update date Mar 01, 2022
Contact name Kinya Yokoyama
Organization name Nagoya University Hospital
Department Neurosurgery
Street address Tsurumai 65
City Showa-ku, Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
 
Platforms (1)
GPL16699 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version)
Samples (20)
GSM4771802 MiddleCerebralArtery_MoyamoyaDisease#84_rep1 [MMD1 ]
GSM4771803 MiddleCerebralArtery_MoyamoyaDisease#95_rep1 [MMD2]
GSM4771804 MiddleCerebralArtery_MoyamoyaDisease#98_rep1 [MMD3]
Relations
BioProject PRJNA662265

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE157628_RAW.tar 246.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
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