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| Status |
Public on Apr 12, 2021 |
| Title |
Reduced representation bisulfite sequencing in liver of rats exposed to glyphosate, MON 52276, and a mixture of pesticides |
| Organism |
Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Human health effects from chronic exposure to pesticide residues are little investigated. We compared standard histopathology and serum biochemistry measures and multi-omics analyses in an in vivo subchronic toxicity test of a glyphosate, its formulated product MON 52276, and mixture of six pesticide active ingredients frequently detected in foodstuffs (azoxystrobin, boscalid, chlorpyrifos, glyphosate, imidacloprid and thiabendazole). Sprague-Dawley rats were administered with the pesticide mixture with each ingredient at its regulatory permitted acceptable daily intake.
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| Overall design |
Evaluation of methylation profiles in liver of rats exposed to glyphosate, MON 52276, and a mixture of pesticides
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| Contributor(s) |
Mesnage R, Mein CA |
| Citation(s) |
33854195, 34850229, 38866738 |
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| Submission date |
Sep 05, 2020 |
| Last update date |
Jun 28, 2024 |
| Contact name |
Robin Mesnage |
| E-mail(s) |
robinmes@gmail.com
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| Phone |
+447482206767
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| Organization name |
Kings College London
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| Street address |
Guy's Hospital, 8th Floor, Tower Wing
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| City |
London |
| ZIP/Postal code |
SE1 9RT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL20084 |
Illumina NextSeq 500 (Rattus norvegicus) |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA661685 |
| SRA |
SRP280230 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE157551_methylated_counts.csv.gz |
110.9 Mb |
(ftp)(http) |
CSV |
| GSE157551_unmethylated_counts.csv.gz |
115.6 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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