|
| Status |
Public on Aug 29, 2020 |
| Title |
Cis-acting lnc-eRNA SEELA1/2 in leukemia progression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Long non-coding enhancer RNAs (lnc-eRNAs) are a subset of stable eRNAs identified from the annotated lncRNAs. They might serve as enhancer activity-related therapeutic targets in cancer; however, the epigenetic activation mechanisms and the function of lnc-eRNAs in cancer initiation and progression remain largely unknown.Here, by genome-wide screening we firstly identified a set of lncRNAs as lnc-eRNAs according to the epigenetic signatures of enhancers.To demonstrate the functional roles of lnc-eRNAs, two newly identified lnc-eRNAs, SEELA1 and SEELA2, were chosen for further studies.Further studies showed that SEELA1/2-SERINC2 axis regulated cancer metabolism, such as sphingolipid synthesis, to affect the leukemia progression.
|
| |
|
| Overall design |
si-NC,si-SEELA1,and si-SERINC2 MV4;11 cells used
|
| |
|
| Contributor(s) |
Chen Y, Fang K, Huang W, Wang W |
| Citation(s) |
33143730 |
| |
| Submission date |
Aug 28, 2020 |
| Last update date |
Nov 09, 2020 |
| Contact name |
Wen-Tao Wang |
| E-mail(s) |
wangwt8@mail.sysu.edu.cn
|
| Phone |
86-20-84111736
|
| Organization name |
sun yat sen university
|
| Department |
School of Life Sciences
|
| Lab |
Key Laboratory of Gene Engineering of the Ministry of Education
|
| Street address |
No. 135, Xingang Xi Road
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510275 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA659934 |
| SRA |
SRP279179 |
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