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| Status |
Public on Sep 09, 2023 |
| Title |
Single cell RNA analysis reveals the complex heterogeneity of CD4+ T cells in chronic neuroinflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Multiple sclerosis (MS) is a severe chronic inflammatory disease of the central nervous system (CNS) that leads to disability in young adults. T lymphocytes are a key component of lesion pathology throughout the disease course. Here we used the animal model experimental autoimmune encephalomyelitis (EAE) to conduct an unbiased characterization of CD4+ T cells in acute and chronic EAE.
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| Overall design |
We identified five distinct CNS CD4+ T cell populations, of which three have not yet been characterized in EAE: innate-like CD4+ T cells (Ccl5, Gzmk, NKG7), tissue resident memory T cells (Cxcr6, Bhlhe40) and lymphoid-tissue like T cells (Klf2, S1pr1, Sell).
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| Contributor(s) |
Crowley T, Rosiewicz KS, Fischer C, Kerkering J, Alisch M, Siffrin V |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 13, 2020 |
| Last update date |
Sep 09, 2023 |
| Contact name |
Cornelius Fischer |
| E-mail(s) |
Cornelius.Fischer@mdc-berlin.de
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| Organization name |
Max Delbrück Center for Molecular Medicine (MDC)
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| Department |
Berlin Institute for Medical Systems Biology
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| Lab |
Genomics Platform
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| Street address |
Robert-Rössle-Straße 10
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| City |
Berlin |
| State/province |
Berlin |
| ZIP/Postal code |
13125 |
| Country |
Germany |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA657035 |
| SRA |
SRP277408 |
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