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| Status |
Public on Jul 18, 2023 |
| Title |
Global transcriptional response to electron acceptors AKB and pyruvate in K562 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report the effects of two metabolites alpha-ketobutyrate and pyruvate on transcription of K562 cells. Increased cell size associates with electron acceptor limitation. Using four replicates per condition, we find that electron acceptors alleviate endoplasmic reticulum stress response in these cells as evidenced by reduction of amino acid transporter as well as ATF4 and CHOP expression.
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| |
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| Overall design |
mRNA proflies of K562 cells treated with alpha-ketobutyrate, pyruvate compared to untreated control cells
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| |
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| Contributor(s) |
Bjorklund M, Cheng Y |
| Citation missing |
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| |
| Submission date |
Jul 19, 2020 |
| Last update date |
Jul 18, 2023 |
| Contact name |
Mikael Bjorklund |
| E-mail(s) |
mikaelbj@intl.zju.edu.cn
|
| Organization name |
Zhejiang University-University of Edinburgh Institute
|
| Street address |
718, Haizhoudong Road, Xiashi Street
|
| City |
Haining |
| State/province |
Zhejiang |
| ZIP/Postal code |
314400 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA647188 |
| SRA |
SRP272472 |
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