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| Status |
Public on Sep 15, 2021 |
| Title |
Metformin Ingestion Rejuvenates Myoblasts from Older Adult Donors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We tested the hypothesis that 2-weeks of metformin ingestion in healthy older adults would improve intrinsic age-related deficits in myoblast (activated satellite cell) function as tested by a series of in vitro functional assays to determine proliferation, fusion index, and myoblast-endothelial cell homing.
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| Overall design |
Myoblasts were isolated from muscle biopsied from healthy community dwelling older (4m/4f, 69y) adult participants before (pre) and after (post) the metformin ingestion period. Myoblasts were harvested from young participants (4m/4f, 27y) to serve as a “youthful” comparator.
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| Contributor(s) |
Mahmassani ZS, Reidy PT, McKenzie AI, Petrocelli JJ, Fix DK, de Hart N, Ferrara PJ, Funai K, Drummond MJ |
| Citation(s) |
33406027 |
| |
| Submission date |
Jul 07, 2020 |
| Last update date |
Sep 15, 2021 |
| Contact name |
Micah J Drummond |
| Organization name |
The University of Utah
|
| Department |
Physical Therapy and Athletic Training
|
| Lab |
Drummond Lab
|
| Street address |
520 Wakara Way
|
| City |
Salt Lake City |
| State/province |
Utah |
| ZIP/Postal code |
84108 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA644603 |
| SRA |
SRP270674 |
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