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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jul 08, 2020 |
| Title |
JUN promotes abdominal adhesions in mice and humans |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Adhesions are fibrotic scars that form between abdominal organs following surgery or infection, and may cause bowel obstruction, chronic pain, or infertility. Adhesions occur post-operatively in 50-90% of all open abdominal operations and as such, represent an enormous clinical problem impacting hundreds of millions of patients worldwide. Our understanding of the biology of adhesion formation is very limited, which explains why there are essentially no available treatments that prevent adhesions. In this study, we systemically analyzed abdominal adhesions in mouse and human tissues gene expression using bulk- and sc-RNA-seq technologies to characterize the fibroblasts responsible for this devastating pathology.
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| Overall design |
Mouse and human abdominal adhesion tissue transcriptomes were profiled using single cell RNA-sequencing. A total of 4 human samples and 2 pooled mouse samples were profiled.
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| Contributor(s) |
Foster D, Januszyk M, Gulati G, Marshall C |
| Citation(s) |
32792541 |
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| Submission date |
Jul 07, 2020 |
| Last update date |
Aug 17, 2020 |
| Contact name |
Michael Januszyk |
| Organization name |
Stanford University
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| Department |
Surgery
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| Street address |
257 Campus Dr
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA644557 |
| SRA |
SRP270639 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE153929_RAW.tar |
128.0 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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