|
| Status |
Public on Sep 30, 2020 |
| Title |
Global Genome Conformational Programming during Neuronal Development by CTCF and nFGFR1 - The Genome Archipelago Model |
| Organism |
Mus musculus |
| Experiment type |
Other
|
| Summary |
This study advances a topologically integrated genome archipelago model that undergoes extensive structural transformations through the formation of nFGFR1-associated Topologically Associated Domains (TADs), replacing CTCF TADs, during the development of the stem cells to neurons. The makeover of the TAD islands serves to recruit distinct ontogenic programs.
|
| |
|
| Overall design |
Examination of chromatin structure alongside previous nFGFR1 binding, and gene expression changes (GSE65698) in mouse stem cells and in neurons. Two biological replicates of HiC, FGFR1 HiChIP, and CTCF HiChIP were completed in both ESC and NCC.
|
| |
|
| Contributor(s) |
Decker B, Liput M, Abdellatif H, Yergeau D, Bae Y, Jornet J, Stachowiak EK, Stachowiak MK |
| Citation(s) |
33396256 |
| |
| Submission date |
Jul 06, 2020 |
| Last update date |
Jan 19, 2021 |
| Contact name |
Brandon Decker |
| E-mail(s) |
bdecker@buffalo.edu
|
| Phone |
585 313 6472
|
| Organization name |
University at Buffalo
|
| Department |
Pathology and Anatomical Sciences
|
| Street address |
955 Main St
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14203 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA644398 |
| SRA |
SRP270351 |
Less...
More...