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| Status |
Public on Apr 17, 2009 |
| Title |
Expression data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, subsequently resulting in a poor long-term prognosis. To model the onset of drug resistance, we measured gene expression alterations associated with cisplatin resistance.
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| |
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| Overall design |
We treated clonally derived, drug-sensitive A2780 epithelial ovarian cancer cells with increasing concentrations of cisplatin. After 5 cycles of drug selection, the isogenic drug-sensitive (parental A2780) and -resistant (Round5 A2780) cell lines were subjected to mRNA expression microarray analyses.
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| |
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| Contributor(s) |
Li M, Nephew KP |
| Citation(s) |
19505326 |
| |
| Submission date |
Mar 24, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Meng Li |
| E-mail(s) |
menli@indiana.edu
|
| Organization name |
Indiana University
|
| Department |
Medical Sciences
|
| Street address |
1001 E 3rd Street
|
| City |
Bloomington |
| State/province |
IN |
| ZIP/Postal code |
47405 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (10)
|
| GSM385721 |
parental A2780 (cisplatin-sensitive), biological rep1 |
| GSM385722 |
parental A2780 (cisplatin-sensitive), biological rep2 |
| GSM385723 |
parental A2780 (cisplatin-sensitive), biological rep3 |
| GSM385724 |
parental A2780 (cisplatin-sensitive), biological rep4 |
| GSM385725 |
parental A2780 (cisplatin-sensitive), biological rep5 |
| GSM385726 |
Round5 A2780 (cisplatin-resistant), biological rep1 |
| GSM385727 |
Round5 A2780 (cisplatin-resistant), biological rep2 |
| GSM385728 |
Round5 A2780 (cisplatin-resistant), biological rep3 |
| GSM385729 |
Round5 A2780 (cisplatin-resistant), biological rep4 |
| GSM385730 |
Round5 A2780 (cisplatin-resistant), biological rep5 |
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| This SubSeries is part of SuperSeries: |
| GSE15709 |
Expression and methylation data from A2780 (cisplatin-sensitive) and Round5 A2780 (cisplatin-resistant) cell lines |
|
| Relations |
| BioProject |
PRJNA123257 |
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