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| Status |
Public on Jun 25, 2020 |
| Title |
Gene expression profiling of drug-tolerant persister PC9 non-small cell lung cancer cells derived from osimertinib treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Targeting drug tolerant persister (DTP) cells may present a therapeutic opportunity to eliminate residual surviving tumor cells and impede relapse. We sought to identify therapeutically exploitable vulnerabilities in DTP cells using the EGFR-mutant non-small cell lung cancer cell line PC9 as an experimental model. Here we provide RNAseq gene expression profiling data generated from parental PC9 cells compared to PC9 DTP cells generated from nine days of treatment with 2 uM osimertinib. These data can be used to identify genes and pathways which are upregulated in DTP cells, revealing potential therapeutic targets.
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| |
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| Overall design |
two biological replicates of PC9 parental and DTP cells
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| |
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| Contributor(s) |
Nie M, Chen N, Pang H, Hu Z |
| Citation missing |
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| |
| Submission date |
Jun 24, 2020 |
| Last update date |
Jun 27, 2020 |
| Contact name |
Meng Nie |
| E-mail(s) |
doublea8@126.com
|
| Phone |
18810489032
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| Organization name |
Tsinghua University
|
| Street address |
Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
100084 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA641683 |
| SRA |
SRP268690 |
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