|
Status |
Public on Oct 01, 2021 |
Title |
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits (ATAC-Seq) |
Organism |
Homo sapiens |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
Summary |
To investigate the role of the hypothalamus in complex traits, we generated ATAC-seq, RNA-seq, and Promoter Focused Capture C to gain insight into the gene regulatory arcitecture contacting promoters in an embryonic stem cell dervived model of hypothalamic neuron differentiation
|
|
|
Overall design |
We performed ATAC-seq, RNA-seq, and Promoter Focused Capture C on stages of ESC dervived hypothalamic like neuron differentiation (ESC: day 0; HP: day 12; HN: day 27).
|
|
|
Contributor(s) |
Pahl MC, . Grant SA |
Citation(s) |
34799566 |
|
Submission date |
Jun 09, 2020 |
Last update date |
Dec 10, 2021 |
Contact name |
Matthew C Pahl |
E-mail(s) |
pahlm@email.chop.edu
|
Phone |
5704282303
|
Organization name |
Children's Hospital of Philadelphia
|
Department |
Center for Spatial and Functional Genomics
|
Lab |
Struan Grant and Andrew Wells
|
Street address |
3615 Civic Center Blvd
|
City |
Philadelphia |
State/province |
PA |
ZIP/Postal code |
19104 |
Country |
USA |
|
|
Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
Samples (14)
|
GSM4602954 |
Embryonic Stem Cells (ATAC-Seq) Replicate 1 |
GSM4602955 |
Embryonic Stem Cells (ATAC-Seq) Replicate 2 |
GSM4602956 |
Embryonic Stem Cells (ATAC-Seq) Replicate 3 |
GSM4602957 |
Embryonic Stem Cells (ATAC-Seq) Replicate 4 |
GSM4602958 |
Embryonic Stem Cell dervived Hypothalamic Progenitor-like Cells (ATAC-Seq) Replicate 1 |
GSM4602959 |
Embryonic Stem Cell dervived Hypothalamic Progenitor-like Cells (ATAC-Seq) Replicate 2 |
GSM4602960 |
Embryonic Stem Cell dervived Hypothalamic Progenitor-like Cells (ATAC-Seq) Replicate 3 |
GSM4602961 |
Embryonic Stem Cell dervived Hypothalamic Progenitor-like Cells (ATAC-Seq) Replicate 4 |
GSM4602962 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 1 |
GSM4602963 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 2 |
GSM4602964 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 3 |
GSM4602965 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 4 |
GSM4602966 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 5 |
GSM4602967 |
Embryonic Stem Cell dervived Hypothalamus-like Neurons (ATAC-Seq) Replicate 6 |
|
This SubSeries is part of SuperSeries: |
GSE152098 |
Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits |
|
Relations |
BioProject |
PRJNA638302 |
SRA |
SRP266588 |