 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 03, 2020 |
| Title |
C9orf72 in myeloid cells suppresses STING-induced inflammation |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In this study we report that loss of C9orf72 expression in myeloid cells drives STING/type I interferon mediated autoimmunity and enhanced tumor immunity in mice. Additionally, we show that the immunophenotypic signature identified in C9orf72-/- mice is present in blood derived macrophages, whole blood and autopsy brain tissue from C9orf72 repeat expansion ALS/FTD patients.
|
| |
|
| Overall design |
DCs: 4 WT & 4 C9orf72 KO; Bcells, CD4, CD8 & CD11B: 4 WT, 4 Cx3Cr1-CRE conditional C9orf72 KO, 3 C9orf72 KO & 4 C9orf72 KO x Golden Ticket (Tmem173 KO); hMDMs: 5 Normal Controls, 5 with C9ORF72 expansion & 5 Sporadic ALS; hMDMs_H151: 2 C9ORF72 expansion samples treated with H151 & the same 2 C9ORF72 expansion samples treated with DMSO
|
| |
|
| Contributor(s) |
McCauley ME, O’Rourke JG, Yáñez A, Markman JL, Ho R, Wang X, Jin M, Muhammad AG, Bell S, Landeros J, Valencia V, Harms M, Arditi M, Jefferies C, Baloh RH |
| Citation(s) |
32814898 |
| |
| Submission date |
Jun 06, 2020 |
| Last update date |
Oct 13, 2022 |
| Contact name |
Shaughn Bell |
| E-mail(s) |
shaughn.bell@cshs.org
|
| Organization name |
Cedars-Sinai Medical Center
|
| Department |
Regenerative Medicine Institute
|
| Street address |
8700 Beverly Blvd
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90048 |
| Country |
USA |
| |
|
| Platforms (2) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (87)
|
|
| Relations |
| BioProject |
PRJNA637768 |
| SRA |
SRP266242 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151936_Bcells_TPM_sum_to_gene.csv.gz |
978.1 Kb |
(ftp)(http) |
CSV |
| GSE151936_CD11b_TPM_sum_to_gene.csv.gz |
990.5 Kb |
(ftp)(http) |
CSV |
| GSE151936_CD4_TPM_sum_to_gene.csv.gz |
994.0 Kb |
(ftp)(http) |
CSV |
| GSE151936_CD8_TPM_sum_to_gene.csv.gz |
977.3 Kb |
(ftp)(http) |
CSV |
| GSE151936_SplDC_RPKM.csv.gz |
539.8 Kb |
(ftp)(http) |
CSV |
| GSE151936_hMDM_H151_TPM_sum_to_gene.csv.gz |
711.9 Kb |
(ftp)(http) |
CSV |
| GSE151936_hMDM_RPKM.csv.gz |
1.0 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...