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| Status |
Public on Oct 16, 2020 |
| Title |
Racial Disparities in Epigenetic Aging of the Right versus the Left Colon |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Here, we present the first study showing race and side-specific differences in the trajectories of epigenetic aging in normal colonic mucosa. The cohort conisted of matched biopsies of left/right colon from healthy individuals (n=129). The majority of individuals were African American (n=89). Methylation arrays (Illumina EPIC) were performed on DNA extracted from fresh frozen biopsies taken at the time of colonoscopy. Our results provide novel insight of epigenetic aging underlying racial disparities in CRC. Side-specific colonic epigenetic aging may be a promising marker to guide interventions to reduce CRC burden.
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| Overall design |
Matched left and right colon biopsies from 129 individuals were analyzed using the Illumina EPIC array.
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| Contributor(s) |
Devall M, Sun X, Yuan F, Cooper GS, Willis J, Weisenberger D, Casey G, Li L |
| Citation(s) |
33377907 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| P20 CA233216 |
Case Comprehensive Cancer Center (Case CCC) Cancer Health Disparities SPORE Planning Grant |
CASE WESTERN RESERVE UNIVERSITY |
LI LI |
| P50 CA150964 |
Detection of Advanced Adenoma Via Stool DNA (sDNA) Methylation Testing |
CASE WESTERN RESERVE UNIVERSITY |
LI LI |
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| |
| Submission date |
Jun 03, 2020 |
| Last update date |
Jan 19, 2021 |
| Contact name |
Matthew Devall |
| E-mail(s) |
mad6kj@virginia.edu
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| Organization name |
University of Virginia
|
| Street address |
1335 Lee Street
|
| City |
Charlottesville |
| State/province |
Virginia |
| ZIP/Postal code |
22908 |
| Country |
USA |
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| Platforms (1) |
| GPL23976 |
Illumina Infinium HumanMethylation850 BeadChip |
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| Samples (256)
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| Relations |
| BioProject |
PRJNA637075 |
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